tooluniverse-gwas-trait-to-gene
Discover genes associated with diseases and traits using GWAS data from the GWAS Catalog (500,000+ associations) and Open Targets Genetics (L2G predictions). Identifies genetic risk factors, prioritizes causal genes via locus-to-gene scoring, and assesses druggability. Use when asked to find genes associated with a disease or trait, discover genetic risk factors, translate GWAS signals to gene targets, or answer questions like "What genes are associated with type 2 diabetes?
npx skills add BioTender-max/awesome-bio-agent-skills --skill tooluniverse-gwas-trait-to-gene --agent claude-code
Same command for any agent — swap --agent for codex, cursor, copilot.
Weekly change comes from our own snapshots, not the repository page — it measures attention, not adoption.
# GWAS Trait-to-Gene Discovery **Discover genes associated with diseases and traits using genome-wide association studies (GWAS)** ## Overview This skill enables systematic discovery of genes linked to diseases/traits by analyzing GWAS data from two major resources: - **GWAS Catalog** (EBI/NHGRI): Curated catalog of published GWAS with >500,000 associations - **Open Targets Genetics**: Fine-mapped GWAS signals with locus-to-gene (L2G) predictions ## Use Cases **Clinical Research** - "What genes are associated with type 2 diabetes?" - "Find genetic risk factors for coronary artery disease" - "Which genes contribute to Alzheimer's disease susceptibility?" **Drug Target Discovery** - Identify genes with strong genetic evidence for disease causation - Prioritize targets based on L2G scores and replication across studies - Find genes with genome-wide significant associations (p < 5e-8) **Functional Genomics** - Map disease-associated variants to candidate genes - Analyze genetic architecture of complex traits - Understand polygenic disease mechanisms ## Workflow ``` 1. Trait Search → Search GWAS Catalog by disease/trait name ↓ 2. SNP Aggregation → Collect genome-wide significant SNPs (p
- Overview
- Use Cases
- Workflow
- Key Concepts
- Required ToolUniverse Tools
- GWAS Catalog (11 tools)
- Open Targets Genetics (6 tools)
- Parameters
- Output Schema
- Example Results
- Best Practices
- Limitations
- Related Skills
- Data Sources
What does the tooluniverse-gwas-trait-to-gene skill do?
Discover genes associated with diseases and traits using GWAS data from the GWAS Catalog (500,000+ associations) and Open Targets Genetics (L2G predictions). Identifies genetic risk factors, prioritizes causal genes via locus-to-gene scoring, and assesses druggability. Use when asked to find genes associated with a disease or trait, discover genetic risk factors, translate GWAS signals to gene targets, or answer questions like "What genes are associated with type 2 diabetes?
How do I install it?
Run `npx skills add BioTender-max/awesome-bio-agent-skills --skill tooluniverse-gwas-trait-to-gene --agent claude-code` — it drops the skill into your project so the agent can pick it up. Swap the --agent value for codex, cursor or copilot if you use one of those.
Where does this skill come from?
From BioTender-max/awesome-bio-agent-skills, a repository with 135 stars. We read it straight from the repository tree rather than a submitted listing, so what you see here is what is actually published.
Is a popular skill a good skill?
Not necessarily. Stars measure attention, not adoption — a repository can trend for a week and be abandoned. That is why we show the weekly change from our own snapshots next to the total, instead of a single flattering number.