tooluniverse-gwas-study-explorer
Compare GWAS studies, perform meta-analyses, and assess replication across cohorts. Integrates NHGRI-EBI GWAS Catalog and Open Targets Genetics to compare study designs, effect sizes, ancestry diversity, and heterogeneity statistics. Use when comparing GWAS studies for a trait, performing meta-analysis of genetic loci, assessing replication across cohorts, or exploring the genetic architecture of complex diseases.
npx skills add BioTender-max/awesome-bio-agent-skills --skill tooluniverse-gwas-study-explorer --agent claude-code
Same command for any agent — swap --agent for codex, cursor, copilot.
Weekly change comes from our own snapshots, not the repository page — it measures attention, not adoption.
# GWAS Study Deep Dive & Meta-Analysis **Compare GWAS studies, perform meta-analyses, and assess replication across cohorts** --- ## Overview The GWAS Study Deep Dive & Meta-Analysis skill enables comprehensive comparison of genome-wide association studies (GWAS) for the same trait, meta-analysis of genetic loci across studies, and systematic assessment of replication and study quality. It integrates data from the NHGRI-EBI GWAS Catalog and Open Targets Genetics to provide a complete picture of the genetic architecture of complex traits. ### Key Capabilities 1. **Study Comparison**: Compare all GWAS studies for a trait, assessing sample sizes, ancestries, and platforms 2. **Meta-Analysis**: Aggregate effect sizes across studies and calculate heterogeneity statistics 3. **Replication Assessment**: Identify replicated vs novel findings across discovery and replication cohorts 4. **Quality Evaluation**: Assess statistical power, ancestry diversity, and data availability --- ## Use Cases ### 1. Comprehensive Trait Analysis **Scenario**: "I want to understand all available GWAS data for type 2 diabetes" **Workflow**: - Search for all T2D studies in GWAS Catalog - Filter by sample size a
- Overview
- Key Capabilities
- Use Cases
- 1. Comprehensive Trait Analysis
- 2. Locus-Specific Meta-Analysis
- 3. Replication Analysis
- 4. Multi-Ancestry Comparison
- Statistical Methods
- Meta-Analysis Approach
- Sources of Heterogeneity
- Study Quality Assessment
- Quality Metrics
- Quality Tiers
- Best Practices
What does the tooluniverse-gwas-study-explorer skill do?
Compare GWAS studies, perform meta-analyses, and assess replication across cohorts. Integrates NHGRI-EBI GWAS Catalog and Open Targets Genetics to compare study designs, effect sizes, ancestry diversity, and heterogeneity statistics. Use when comparing GWAS studies for a trait, performing meta-analysis of genetic loci, assessing replication across cohorts, or exploring the genetic architecture of complex diseases.
How do I install it?
Run `npx skills add BioTender-max/awesome-bio-agent-skills --skill tooluniverse-gwas-study-explorer --agent claude-code` — it drops the skill into your project so the agent can pick it up. Swap the --agent value for codex, cursor or copilot if you use one of those.
Where does this skill come from?
From BioTender-max/awesome-bio-agent-skills, a repository with 135 stars. We read it straight from the repository tree rather than a submitted listing, so what you see here is what is actually published.
Is a popular skill a good skill?
Not necessarily. Stars measure attention, not adoption — a repository can trend for a week and be abandoned. That is why we show the weekly change from our own snapshots next to the total, instead of a single flattering number.