retrosynthesis-guide
Retrosynthetic analysis and computational reaction prediction
Profile →npx skills add brycewang-stanford/Auto-Empirical-Research-Skills --skill retrosynthesis-guide --agent claude-code
Same command for any agent — swap --agent for codex, cursor, copilot.
Weekly change comes from our own snapshots, not the repository page — it measures attention, not adoption.
# Retrosynthesis Guide Plan synthetic routes for target molecules using retrosynthetic analysis principles and computational tools, from Corey's logic to modern AI-driven approaches. ## What Is Retrosynthesis? Retrosynthesis works backward from a target molecule to identify simpler, commercially available precursors: ``` Target Molecule (TM) | [Disconnection 1] ← Apply transform (reverse of a known reaction) | Synthon A + Synthon B | | [Available] [Disconnection 2] | Synthon C + Synthon D | | [Available] [Available] ``` Key terminology: - **Target Molecule (TM)**: The molecule you want to synthesize - **Synthon**: Idealized reactive fragment from a disconnection - **Synthetic Equivalent**: Real reagent corresponding to a synthon - **Transform**: Reverse of a chemical reaction (retro-reaction) - **FGI (Functional Group Interconversion)**: Convert one functional group to another to enable a disconnection ## Corey's Retrosynthetic Strategies ### Strategic Bond Disconnections | Strategy | Description | When to Use | |----------|-------------|------------| | **FGI** | Convert functional groups to enable disconnections | When direct disconnection is not possible | | **C-C Bond disconnect
- What Is Retrosynthesis?
- Corey's Retrosynthetic Strategies
- Strategic Bond Disconnections
- Common Disconnection Patterns
- Computational Retrosynthesis Tools
- Tool Comparison
- Using ASKCOS
- Using IBM RXN for Chemistry
- Using AiZynthFinder (Open Source)
- SMILES Notation for Chemistry
- Reaction Databases
- Best Practices for Route Planning
What does the retrosynthesis-guide skill do?
Retrosynthetic analysis and computational reaction prediction
How do I install it?
Run `npx skills add brycewang-stanford/Auto-Empirical-Research-Skills --skill retrosynthesis-guide --agent claude-code` — it drops the skill into your project so the agent can pick it up. Swap the --agent value for codex, cursor or copilot if you use one of those.
Where does this skill come from?
From brycewang-stanford/Auto-Empirical-Research-Skills, a repository with 3,244 stars. We read it straight from the repository tree rather than a submitted listing, so what you see here is what is actually published.
Is a popular skill a good skill?
Not necessarily. Stars measure attention, not adoption — a repository can trend for a week and be abandoned. That is why we show the weekly change from our own snapshots next to the total, instead of a single flattering number.