recombinator
Produce offspring genomes from parent pairs via meiotic recombination, mutation, and clinical evaluation
npx skills add BioTender-max/awesome-bio-agent-skills --skill recombinator --agent claude-code
Same command for any agent — swap --agent for codex, cursor, copilot.
Weekly change comes from our own snapshots, not the repository page — it measures attention, not adoption.
# 🧪 Recombinator ## Purpose Produce offspring genomes from selected parent pairs via simulated meiotic recombination. Models Mendelian segregation, de novo mutation, sex determination, and clinical evaluation against a disease registry. ## How It Works 1. **Mendelian segregation**: one allele inherited from each parent per locus (random selection simulating independent assortment). 2. **De novo mutation**: configurable rate per locus (default 0.1%), with hotspot multipliers for cognitive, immune, and metabolic loci. Mutations are classified as disease-risk, protective, or neutral. 3. **Sex determination**: 50/50 coin flip (XY or XX). 4. **Trait inference**: reverse-map offspring genotype back to trait scores using the trait registry, accounting for dominance models. 5. **Clinical evaluation**: check offspring genotype against disease registry for penetrance, onset probability, and fitness cost. 6. **Health score**: computed from cumulative fitness costs of clinical conditions. ## Input - Two parent `.genome.json` files (one Male, one Female) - `GENOMEBOOK/DATA/trait_registry.json` - `GENOMEBOOK/DATA/disease_registry.json` ## Output - Offspring `.genome.json` with: - Inherited loci
- Purpose
- How It Works
- Input
- Output
- CLI Usage
- Output Format
python skills/recombinator/recombinator.py --demo Breed specific parents python skills/recombinator/recombinator.py \ Custom generation number
What does the recombinator skill do?
Produce offspring genomes from parent pairs via meiotic recombination, mutation, and clinical evaluation
How do I install it?
Run `npx skills add BioTender-max/awesome-bio-agent-skills --skill recombinator --agent claude-code` — it drops the skill into your project so the agent can pick it up. Swap the --agent value for codex, cursor or copilot if you use one of those.
Where does this skill come from?
From BioTender-max/awesome-bio-agent-skills, a repository with 135 stars. We read it straight from the repository tree rather than a submitted listing, so what you see here is what is actually published.
Is a popular skill a good skill?
Not necessarily. Stars measure attention, not adoption — a repository can trend for a week and be abandoned. That is why we show the weekly change from our own snapshots next to the total, instead of a single flattering number.