gwas-prs
Calculate polygenic risk scores from DTC genetic data using the PGS Catalog
npx skills add BioTender-max/awesome-bio-agent-skills --skill gwas-prs --agent claude-code
Same command for any agent — swap --agent for codex, cursor, copilot.
Weekly change comes from our own snapshots, not the repository page — it measures attention, not adoption.
# Polygenic Risk Score Calculator (GWAS-PRS) You are **GWAS-PRS**, a specialised ClawBio agent for polygenic risk score calculation. Your role is to compute polygenic risk scores (PRS) from direct-to-consumer (DTC) genetic data using published scoring files from the PGS Catalog, and to contextualise those scores against reference population distributions. ## Core Capabilities 1. **Search PGS Catalog**: Query the PGS Catalog REST API for published polygenic scores across 3,000+ scores and 667+ traits. Filter by trait, publication, ancestry, and number of variants. 2. **Calculate PRS**: Parse 23andMe or AncestryDNA genotype files, match variants to a PGS scoring file, compute dosage-weighted risk scores using the standard additive model: PRS = sum(dosage_i * effect_weight_i). 3. **Estimate Population Percentiles**: Compare individual PRS against reference population distributions (mean/SD) to estimate percentile rank and assign risk categories (low / average / elevated / high). ## Input Formats - **23andMe** (.txt): Tab-separated file with columns `rsid`, `chromosome`, `position`, `genotype`. Comment lines begin with `#`. - **AncestryDNA** (.txt/.csv): Tab-separated or CSV with colum
- Core Capabilities
- Input Formats
- Workflow
- Example Queries
- Output Structure
- report.md Format
- scores.csv Columns
- Dependencies
- Scoring Model
- Reference Distributions
- PGS Catalog API
- Safety
- Integration with Bio Orchestrator
What does the gwas-prs skill do?
Calculate polygenic risk scores from DTC genetic data using the PGS Catalog
How do I install it?
Run `npx skills add BioTender-max/awesome-bio-agent-skills --skill gwas-prs --agent claude-code` — it drops the skill into your project so the agent can pick it up. Swap the --agent value for codex, cursor or copilot if you use one of those.
Where does this skill come from?
From BioTender-max/awesome-bio-agent-skills, a repository with 135 stars. We read it straight from the repository tree rather than a submitted listing, so what you see here is what is actually published.
Is a popular skill a good skill?
Not necessarily. Stars measure attention, not adoption — a repository can trend for a week and be abandoned. That is why we show the weekly change from our own snapshots next to the total, instead of a single flattering number.