genome-match
Score genetic compatibility across all male-female pairings in a Genomebook generation
npx skills add BioTender-max/awesome-bio-agent-skills --skill genome-match --agent claude-code
Same command for any agent — swap --agent for codex, cursor, copilot.
Weekly change comes from our own snapshots, not the repository page — it measures attention, not adoption.
# 💞 GenomeMatch ## Purpose Score genetic compatibility between all male-female pairings in a Genomebook generation. The engine evaluates heterozygosity advantage, disease carrier risk, and trait complementarity to rank optimal mating pairs for the next generation. ## How It Works 1. **Load genomes** for a target generation from `GENOMEBOOK/DATA/GENOMES/`. 2. **Compute pairwise compatibility** for every M x F combination: - **Heterozygosity score (40%)**: fraction of loci where offspring would be heterozygous (genetic diversity advantage). - **Trait complementarity (40%)**: reward balanced trait combinations and high average trait values across the pair. - **Disease risk penalty (20%)**: flag pairs where both parents carry recessive disease alleles (25% affected offspring risk per flagged condition). 3. **Rank all pairings** by composite score (0.0 to 1.0). 4. **Select non-overlapping mating pairs** via greedy selection from the top of the ranked list (each individual mates at most once per generation). ## Input - `GENOMEBOOK/DATA/GENOMES/*.genome.json` - `GENOMEBOOK/DATA/disease_registry.json` ## Output - Ranked compatibility table (all M x F pairings) - Selected mating pairs for
- Purpose
- How It Works
- Input
- Output
- CLI Usage
- Output Format
Score all pairings for generation 0 python skills/genome-match/genome_match.py Score a specific generation python skills/genome-match/genome_match.py --generation 1 Demo mode python skills/genome-match/genome_match.py --demo Limit output to top N pairings python skills/genome-match/genome_match.py --top 10
What does the genome-match skill do?
Score genetic compatibility across all male-female pairings in a Genomebook generation
How do I install it?
Run `npx skills add BioTender-max/awesome-bio-agent-skills --skill genome-match --agent claude-code` — it drops the skill into your project so the agent can pick it up. Swap the --agent value for codex, cursor or copilot if you use one of those.
Where does this skill come from?
From BioTender-max/awesome-bio-agent-skills, a repository with 135 stars. We read it straight from the repository tree rather than a submitted listing, so what you see here is what is actually published.
Is a popular skill a good skill?
Not necessarily. Stars measure attention, not adoption — a repository can trend for a week and be abandoned. That is why we show the weekly change from our own snapshots next to the total, instead of a single flattering number.