Agent skill

genome-compare

Compare your genome to George Church (PGP-1) and estimate ancestry composition via IBS and EM admixture

BioTender-maxgithub.com/BioTender-maxGitHub ↗
claude-codeships scriptsNOASSERTION
Install
npx skills add BioTender-max/awesome-bio-agent-skills --skill genome-compare --agent claude-code

Same command for any agent — swap --agent for codex, cursor, copilot.

Facts
Files in the skill folder: 9
SKILL.md size: 5 KB
Bundled scripts: yes
Version: 0.1.0
Declared author: Manuel Corpas
Path: skills/clawbio/genome-compare/SKILL.md
Open the folder on GitHub →
Where it comes from
Stars: 135
Language: Python

Weekly change comes from our own snapshots, not the repository page — it measures attention, not adoption.

From the SKILL.md

# 🧬 Genome Comparator You are the **Genome Comparator**, a specialised ClawBio skill for pairwise genome comparison and ancestry estimation. ## Why This Exists - **Without it**: Comparing two genomes requires PLINK, custom scripts, and ancestry reference panels — hours of bioinformatics setup - **With it**: Upload a 23andMe file and instantly see IBS similarity to George Church, per-chromosome breakdown, and ancestry composition - **Why ClawBio**: Uses a bundled PGP-1 reference genome (CC0 public domain) and an EM admixture algorithm calibrated to continental ancestry-informative markers ## Core Capabilities 1. **Identity By State (IBS)**: Compare a user's genome against George Church's public 23andMe data (PGP-1, hu43860C). Report SNP overlap, identity, and relationship context. 2. **Ancestry Composition**: Estimate continental ancestry proportions (African, European, East Asian, South Asian, Americas) from ancestry-informative markers using an EM admixture algorithm. 3. **Chromosome Breakdown**: Show per-chromosome IBS scores and overlap counts. ## Input Formats | Format | Extension | Required Fields | Example | |--------|-----------|-----------------|---------| | 23andMe raw da

What's inside
Steps it walks through
  1. Why This Exists
  2. Core Capabilities
  3. Input Formats
  4. Reference Genome
  5. Workflow
  6. CLI Reference
  7. Demo
  8. Output Structure
  9. Dependencies
  10. Safety
  11. Integration with Bio Orchestrator
  12. Citations
Ships with 8 files
  • __init__.py
  • api.py
  • data/aims_panel.json
  • data/george_church_23andme.txt.gz
  • data/manuel_ancestry.json
  • data/manuel_corpas_23andme.txt.gz
  • genome_compare.py
  • tests/test_genome_compare.py
Commands it runs
python skills/genome-compare/genome_compare.py --demo --output results/
Your own data vs George Church
python skills/genome-compare/genome_compare.py --input your_23andme.txt --output results/
Via ClawBio runner
python clawbio.py run compare --demo
python clawbio.py run compare --input <file> --output <dir>
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About this skill
What does the genome-compare skill do?

Compare your genome to George Church (PGP-1) and estimate ancestry composition via IBS and EM admixture

How do I install it?

Run `npx skills add BioTender-max/awesome-bio-agent-skills --skill genome-compare --agent claude-code` — it drops the skill into your project so the agent can pick it up. Swap the --agent value for codex, cursor or copilot if you use one of those.

Where does this skill come from?

From BioTender-max/awesome-bio-agent-skills, a repository with 135 stars. We read it straight from the repository tree rather than a submitted listing, so what you see here is what is actually published.

Is a popular skill a good skill?

Not necessarily. Stars measure attention, not adoption — a repository can trend for a week and be abandoned. That is why we show the weekly change from our own snapshots next to the total, instead of a single flattering number.

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