tmb-msi-calculator
Tumor mutation burden and microsatellite instability calculation skill for immunotherapy biomarkers
Profile →npx skills add a5c-ai/babysitter --skill tmb-msi-calculator --agent claude-code
Same command for any agent — swap --agent for codex, cursor, copilot.
Weekly change comes from our own snapshots, not the repository page — it measures attention, not adoption.
# TMB-MSI Calculator Skill ## Purpose Calculate tumor mutation burden and microsatellite instability for immunotherapy biomarker assessment. ## Capabilities - TMB calculation from VCF - MSI status determination - Neoantigen prediction - HLA typing integration - Biomarker thresholds - Clinical report generation ## Usage Guidelines - Calculate TMB with appropriate normalization - Determine MSI status accurately - Predict neoantigens for immunotherapy - Apply clinical thresholds for reporting - Generate actionable reports - Document methodology and thresholds ## Dependencies - TMBcat - MSIsensor2 - MANTIS ## Process Integration - Tumor Molecular Profiling (tumor-molecular-profiling)
- Purpose
- Capabilities
- Usage Guidelines
- Dependencies
- Process Integration
What does the tmb-msi-calculator skill do?
Tumor mutation burden and microsatellite instability calculation skill for immunotherapy biomarkers
How do I install it?
Run `npx skills add a5c-ai/babysitter --skill tmb-msi-calculator --agent claude-code` — it drops the skill into your project so the agent can pick it up. Swap the --agent value for codex, cursor or copilot if you use one of those.
Where does this skill come from?
From a5c-ai/babysitter, a repository with 1,642 stars. We read it straight from the repository tree rather than a submitted listing, so what you see here is what is actually published.
Is a popular skill a good skill?
Not necessarily. Stars measure attention, not adoption — a repository can trend for a week and be abandoned. That is why we show the weekly change from our own snapshots next to the total, instead of a single flattering number.