lancet-study-design
Use to lock study design and mandatory prospective registration for a Lancet clinical manuscript — trial registration before enrollment, protocol + statistical analysis plan, and design rigor (randomization, allocation concealment, blinding, pre-specified endpoints, power, ITT). Covers observational design choices too.
Profile →npx skills add brycewang-stanford/Awesome-Journal-Skills --skill lancet-study-design --agent claude-code
Same command for any agent — swap --agent for codex, cursor, copilot.
Weekly change comes from our own snapshots, not the repository page — it measures attention, not adoption.
# Study Design & Registration (lancet-study-design) ## When to trigger - Planning or writing up a clinical trial or a major observational study. - The trial registration number is missing, or registration timing is unclear. - There is no protocol or no pre-specified statistical analysis plan (SAP). - A reviewer is likely to ask "was the primary endpoint pre-specified?" and there is no clear answer. ## Mandatory: prospective trial registration The Lancet follows ICMJE: **clinical trials must be registered prospectively — before the first participant is enrolled — in a WHO-ICTRP primary registry or ClinicalTrials.gov.** - [ ] Registered **before** enrollment of the first participant (retrospective registration is a serious, often fatal, problem — flag it immediately and disclose honestly). - [ ] Registration number reported **in the abstract** and Methods (e.g., ClinicalTrials.gov NCTxxxxxxxx; ISRCTN; or a WHO-ICTRP primary registry). - [ ] Registered outcomes match the reported primary/secondary outcomes; explain and flag any change. | Registry | Use / region | |----------|--------------| | [ClinicalTrials.gov](https://clinicaltrials.gov/) | US and international | | [ISRCTN](https:/
- When to trigger
- Mandatory: prospective trial registration
- Protocol + statistical analysis plan (SAP)
- Trial design rigor (RCT)
- Observational design choices
- What Lancet editors check on design and registration
- Worked micro-example (illustrative numbers — not real data)
- Reviewer-pushback patterns and the venue-specific fix
- Output format
- Anti-patterns
What does the lancet-study-design skill do?
Use to lock study design and mandatory prospective registration for a Lancet clinical manuscript — trial registration before enrollment, protocol + statistical analysis plan, and design rigor (randomization, allocation concealment, blinding, pre-specified endpoints, power, ITT). Covers observational design choices too.
How do I install it?
Run `npx skills add brycewang-stanford/Awesome-Journal-Skills --skill lancet-study-design --agent claude-code` — it drops the skill into your project so the agent can pick it up. Swap the --agent value for codex, cursor or copilot if you use one of those.
Where does this skill come from?
From brycewang-stanford/Awesome-Journal-Skills, a repository with 909 stars. We read it straight from the repository tree rather than a submitted listing, so what you see here is what is actually published.
Is a popular skill a good skill?
Not necessarily. Stars measure attention, not adoption — a repository can trend for a week and be abandoned. That is why we show the weekly change from our own snapshots next to the total, instead of a single flattering number.