jama-study-design
Use when locking the study design and internal-validity safeguards for a JAMA clinical manuscript (RCT, cohort, diagnostic, or systematic review). Strengthens design choices; it does NOT pick the reporting checklist or run the statistics.
Profile →npx skills add brycewang-stanford/Awesome-Journal-Skills --skill jama-study-design --agent claude-code
Same command for any agent — swap --agent for codex, cursor, copilot.
Weekly change comes from our own snapshots, not the repository page — it measures attention, not adoption.
# Study Design & Internal Validity (jama-study-design) ## When to trigger - Choosing or defending the design: RCT vs cohort vs case-control vs diagnostic - A reviewer will ask whether the analysis is intention-to-treat or per-protocol - Bias, confounding, or missing data threaten the primary inference - The design and the reporting checklist need to be aligned before writing ## Design-specific safeguards JAMA reviewers expect ### Randomized clinical trials - A single, **pre-specified primary outcome**; secondary outcomes clearly labeled - Adequate randomization (sequence generation) and **allocation concealment** - Blinding of participants, clinicians, outcome assessors where feasible — state what was blinded - **Intention-to-treat** as the primary analysis; per-protocol only as secondary/sensitivity - A priori **sample-size / power** calculation tied to the primary outcome - Pre-defined stopping rules and handling of interim analyses ### Cohort / case-control (observational) - Explicit **confounding** control: prespecified covariates, adjustment strategy, DAG reasoning - Clear definitions of exposure, outcome, and follow-up windows; avoid immortal-time bias - Selection-bias and in
- When to trigger
- Design-specific safeguards JAMA reviewers expect
- Randomized clinical trials
- Cohort / case-control (observational)
- Diagnostic-accuracy studies
- Systematic reviews / meta-analyses
- Decision table
- Checklist
- Anti-patterns
- Worked example: locking the design (illustrative)
- Reviewer pushback and the JAMA fix
- Operating pass for JAMA
- Output format
What does the jama-study-design skill do?
Use when locking the study design and internal-validity safeguards for a JAMA clinical manuscript (RCT, cohort, diagnostic, or systematic review). Strengthens design choices; it does NOT pick the reporting checklist or run the statistics.
How do I install it?
Run `npx skills add brycewang-stanford/Awesome-Journal-Skills --skill jama-study-design --agent claude-code` — it drops the skill into your project so the agent can pick it up. Swap the --agent value for codex, cursor or copilot if you use one of those.
Where does this skill come from?
From brycewang-stanford/Awesome-Journal-Skills, a repository with 909 stars. We read it straight from the repository tree rather than a submitted listing, so what you see here is what is actually published.
Is a popular skill a good skill?
Not necessarily. Stars measure attention, not adoption — a repository can trend for a week and be abandoned. That is why we show the weekly change from our own snapshots next to the total, instead of a single flattering number.