gtex-database
Query GTEx (Genotype-Tissue Expression) portal for tissue-specific gene expression, eQTLs (expression quantitative trait loci), and sQTLs. Essential for linking GWAS variants to gene regulation, understanding tissue-specific expression, and interpreting non-coding variant effects.
npx skills add LeonChaoX/qinyan-academic-skills --skill gtex-database --agent claude-code
Same command for any agent — swap --agent for codex, cursor, copilot.
Weekly change comes from our own snapshots, not the repository page — it measures attention, not adoption.
# GTEx Database ## Overview The Genotype-Tissue Expression (GTEx) project provides a comprehensive resource for studying tissue-specific gene expression and genetic regulation across 54 non-diseased human tissues from nearly 1,000 individuals. GTEx v10 (the latest release) enables researchers to understand how genetic variants regulate gene expression (eQTLs) and splicing (sQTLs) in a tissue-specific manner, which is critical for interpreting GWAS loci and identifying regulatory mechanisms. **Key resources:** - GTEx Portal: https://gtexportal.org/ - GTEx API v2: https://gtexportal.org/api/v2/ - Data downloads: https://gtexportal.org/home/downloads/adult-gtex/ - Documentation: https://gtexportal.org/home/documentationPage ## When to Use This Skill Use GTEx when: - **GWAS locus interpretation**: Identifying which gene a non-coding GWAS variant regulates via eQTLs - **Tissue-specific expression**: Comparing gene expression levels across 54 human tissues - **eQTL colocalization**: Testing if a GWAS signal and an eQTL signal share the same causal variant - **Multi-tissue eQTL analysis**: Finding variants that regulate expression in multiple tissues - **Splicing QTLs (sQTLs)**: Identifyi
- Overview
- When to Use This Skill
- Core Capabilities
- 1. GTEx REST API v2
- 2. Gene Expression by Tissue
- 3. eQTL Lookup
- 4. Single-Tissue eQTL by Variant
- 5. Multi-Tissue eQTL (eGenes)
- 6. Tissue List
- 7. sQTL (Splicing QTLs)
- Query Workflows
- Workflow 1: Interpreting a GWAS Variant via eQTLs
- Workflow 2: Gene Expression Atlas
- Workflow 3: Tissue-Specific eQTL Analysis
All significant eQTLs (v10) wget https://storage.googleapis.com/adult-gtex/bulk-qtl/v10/single-tissue-cis-qtl/GTEx_Analysis_v10_eQTL.tar Normalized expression matrices wget https://storage.googleapis.com/adult-gtex/bulk-gex/v10/rna-seq/GTEx_Analysis_v10_RNASeQCv2.4.2_gene_reads.gct.gz
What does the gtex-database skill do?
Query GTEx (Genotype-Tissue Expression) portal for tissue-specific gene expression, eQTLs (expression quantitative trait loci), and sQTLs. Essential for linking GWAS variants to gene regulation, understanding tissue-specific expression, and interpreting non-coding variant effects.
How do I install it?
Run `npx skills add LeonChaoX/qinyan-academic-skills --skill gtex-database --agent claude-code` — it drops the skill into your project so the agent can pick it up. Swap the --agent value for codex, cursor or copilot if you use one of those.
Where does this skill come from?
From LeonChaoX/qinyan-academic-skills, a repository with 759 stars. We read it straight from the repository tree rather than a submitted listing, so what you see here is what is actually published.
Is a popular skill a good skill?
Not necessarily. Stars measure attention, not adoption — a repository can trend for a week and be abandoned. That is why we show the weekly change from our own snapshots next to the total, instead of a single flattering number.