genome-compare
Compare your genome to George Church (PGP-1) and estimate ancestry composition via IBS and EM admixture
npx skills add FreedomIntelligence/OpenClaw-Medical-Skills --skill genome-compare --agent claude-code
Same command for any agent — swap --agent for codex, cursor, copilot.
Weekly change comes from our own snapshots, not the repository page — it measures attention, not adoption.
# 🧬 Genome Comparator You are the **Genome Comparator**, a specialised ClawBio skill for pairwise genome comparison and ancestry estimation. ## Why This Exists - **Without it**: Comparing two genomes requires PLINK, custom scripts, and ancestry reference panels — hours of bioinformatics setup - **With it**: Upload a 23andMe file and instantly see IBS similarity to George Church, per-chromosome breakdown, and ancestry composition - **Why ClawBio**: Uses a bundled PGP-1 reference genome (CC0 public domain) and an EM admixture algorithm calibrated to continental ancestry-informative markers ## Core Capabilities 1. **Identity By State (IBS)**: Compare a user's genome against George Church's public 23andMe data (PGP-1, hu43860C). Report SNP overlap, identity, and relationship context. 2. **Ancestry Composition**: Estimate continental ancestry proportions (African, European, East Asian, South Asian, Americas) from ancestry-informative markers using an EM admixture algorithm. 3. **Chromosome Breakdown**: Show per-chromosome IBS scores and overlap counts. ## Input Formats | Format | Extension | Required Fields | Example | |--------|-----------|-----------------|---------| | 23andMe raw da
- Why This Exists
- Core Capabilities
- Input Formats
- Reference Genome
- Workflow
- CLI Reference
- Demo
- Output Structure
- Dependencies
- Safety
- Integration with Bio Orchestrator
- Citations
python skills/genome-compare/genome_compare.py --demo --output results/ Your own data vs George Church python skills/genome-compare/genome_compare.py --input your_23andme.txt --output results/ Via ClawBio runner python clawbio.py run compare --demo python clawbio.py run compare --input <file> --output <dir>
What does the genome-compare skill do?
Compare your genome to George Church (PGP-1) and estimate ancestry composition via IBS and EM admixture
How do I install it?
Run `npx skills add FreedomIntelligence/OpenClaw-Medical-Skills --skill genome-compare --agent claude-code` — it drops the skill into your project so the agent can pick it up. Swap the --agent value for codex, cursor or copilot if you use one of those.
Where does this skill come from?
From FreedomIntelligence/OpenClaw-Medical-Skills, a repository with 2,909 stars. We read it straight from the repository tree rather than a submitted listing, so what you see here is what is actually published.
Is a popular skill a good skill?
Not necessarily. Stars measure attention, not adoption — a repository can trend for a week and be abandoned. That is why we show the weekly change from our own snapshots next to the total, instead of a single flattering number.