cosmic-database
Access COSMIC cancer mutation database. Query somatic mutations, Cancer Gene Census, mutational signatures, gene fusions, for cancer research and precision oncology. Requires authentication.
npx skills add FreedomIntelligence/OpenClaw-Medical-Skills --skill cosmic-database --agent claude-code
Same command for any agent — swap --agent for codex, cursor, copilot.
Weekly change comes from our own snapshots, not the repository page — it measures attention, not adoption.
# COSMIC Database ## Overview COSMIC (Catalogue of Somatic Mutations in Cancer) is the world's largest and most comprehensive database for exploring somatic mutations in human cancer. Access COSMIC's extensive collection of cancer genomics data, including millions of mutations across thousands of cancer types, curated gene lists, mutational signatures, and clinical annotations programmatically. ## When to Use This Skill This skill should be used when: - Downloading cancer mutation data from COSMIC - Accessing the Cancer Gene Census for curated cancer gene lists - Retrieving mutational signature profiles - Querying structural variants, copy number alterations, or gene fusions - Analyzing drug resistance mutations - Working with cancer cell line genomics data - Integrating cancer mutation data into bioinformatics pipelines - Researching specific genes or mutations in cancer contexts ## Prerequisites ### Account Registration COSMIC requires authentication for data downloads: - **Academic users**: Free access with registration at https://cancer.sanger.ac.uk/cosmic/register - **Commercial users**: License required (contact QIAGEN) ### Python Requirements ```bash uv pip install requests
- Overview
- When to Use This Skill
- Prerequisites
- Account Registration
- Python Requirements
- Quick Start
- 1. Basic File Download
- 2. Command-Line Usage
- 3. Working with Downloaded Data
- Available Data Types
- Core Mutations
- Cancer Gene Census
- Mutational Signatures
- Structural Variants and Fusions
uv pip install requests pandas Download using shorthand data type python scripts/download_cosmic.py user@email.com --data-type mutations Download specific file python scripts/download_cosmic.py user@email.com \ Download for specific genome assembly
What does the cosmic-database skill do?
Access COSMIC cancer mutation database. Query somatic mutations, Cancer Gene Census, mutational signatures, gene fusions, for cancer research and precision oncology. Requires authentication.
How do I install it?
Run `npx skills add FreedomIntelligence/OpenClaw-Medical-Skills --skill cosmic-database --agent claude-code` — it drops the skill into your project so the agent can pick it up. Swap the --agent value for codex, cursor or copilot if you use one of those.
Where does this skill come from?
From FreedomIntelligence/OpenClaw-Medical-Skills, a repository with 2,909 stars. We read it straight from the repository tree rather than a submitted listing, so what you see here is what is actually published.
Is a popular skill a good skill?
Not necessarily. Stars measure attention, not adoption — a repository can trend for a week and be abandoned. That is why we show the weekly change from our own snapshots next to the total, instead of a single flattering number.