cdr3aaphyschem
Analyzes physicochemical properties of CDR3 amino acid sequences to understand biochemical characteristics of T-cell receptor repertoires. Performs regression analysis between two cell groups at different CDR3 lengths for each physicochemical feature (hydrophobicity, volume, isoelectric point, etc.).
npx skills add majiayu000/claude-skill-registry --skill cdr3aaphyschem --agent claude-code
Same command for any agent — swap --agent for codex, cursor, copilot.
Weekly change comes from our own snapshots, not the repository page — it measures attention, not adoption.
# CDR3AAPhyschem Process Configuration ## Purpose Analyzes physicochemical properties of CDR3 amino acid sequences to understand biochemical characteristics of T-cell receptor repertoires. Performs regression analysis between two cell groups at different CDR3 lengths for each physicochemical feature (hydrophobicity, volume, isoelectric point, etc.). ## When to Use - To analyze CDR3 biochemical properties differences between cell groups (e.g., Treg vs Tconv) - For feature engineering in TCR machine learning models - To identify sequence features that distinguish cell subsets - After `ScRepCombiningExpression` (requires combined TCR + RNA data) - When investigating T cell fate determination (regulatory vs conventional T cells) ## Configuration Structure ### Process Enablement ```toml [CDR3AAPhyschem] cache = true ``` ### Input Specification ```toml [CDR3AAPhyschem.in] scrfile = ["ScRepCombiningExpression"] ``` - `scrfile`: Output from `ScRepCombiningExpression` (RDS or qs/qs2 format) - Must contain both TRA and TRB chains - Generated by `scRepertoire::combineExpression()` ### Environment Variables ```toml [CDR3AAPhyschem.envs] # Group comparison specification group = "CellType" compa
- Purpose
- When to Use
- Configuration Structure
- Process Enablement
- Input Specification
- Environment Variables
- Configuration Examples
- Minimal Configuration
- Standard Treg vs Tconv Analysis
- Multi-Sample Analysis
- Custom Group Definition
- Physicochemical Properties
- Available Properties
- Property Calculation Methods
What does the cdr3aaphyschem skill do?
Analyzes physicochemical properties of CDR3 amino acid sequences to understand biochemical characteristics of T-cell receptor repertoires. Performs regression analysis between two cell groups at different CDR3 lengths for each physicochemical feature (hydrophobicity, volume, isoelectric point, etc.).
How do I install it?
Run `npx skills add majiayu000/claude-skill-registry --skill cdr3aaphyschem --agent claude-code` — it drops the skill into your project so the agent can pick it up. Swap the --agent value for codex, cursor or copilot if you use one of those.
Where does this skill come from?
From majiayu000/claude-skill-registry, a repository with 534 stars. We read it straight from the repository tree rather than a submitted listing, so what you see here is what is actually published.
Is a popular skill a good skill?
Not necessarily. Stars measure attention, not adoption — a repository can trend for a week and be abandoned. That is why we show the weekly change from our own snapshots next to the total, instead of a single flattering number.