bio-immunoinformatics-mhc-binding-prediction
Predict peptide-MHC class I and II binding affinity using MHCflurry and NetMHCpan neural network models. Identify potential T-cell epitopes from protein sequences. Use when predicting MHC binding for vaccine design or neoantigen identification.
npx skills add FreedomIntelligence/OpenClaw-Medical-Skills --skill bio-immunoinformatics-mhc-binding-prediction --agent claude-code
Same command for any agent — swap --agent for codex, cursor, copilot.
Weekly change comes from our own snapshots, not the repository page — it measures attention, not adoption.
## Version Compatibility Reference examples tested with: MHCflurry 2.1+, pandas 2.2+ Before using code patterns, verify installed versions match. If versions differ: - Python: `pip show <package>` then `help(module.function)` to check signatures - CLI: `<tool> --version` then `<tool> --help` to confirm flags If code throws ImportError, AttributeError, or TypeError, introspect the installed package and adapt the example to match the actual API rather than retrying. # MHC Binding Prediction **"Predict which peptides bind to MHC"** → Predict peptide-MHC class I and II binding affinity using neural network models to identify potential T-cell epitopes from protein sequences. - Python: `mhcflurry.Class1PresentationPredictor().predict()` for MHC-I - CLI: `netMHCpan` for alternative MHC-I/II predictions ## MHCflurry Setup **Goal:** Install MHCflurry and download pre-trained prediction models. **Approach:** Install via pip and fetch model weights for class I pan-allele or specific allele predictions. ```bash # Install MHCflurry pip install mhcflurry # Download prediction models mhcflurry-downloads fetch # Download models for specific alleles mhcflurry-downloads fetch models_class1_pan ``` #
- Version Compatibility
- MHCflurry Setup
- MHCflurry Python API
- Interpret Binding Predictions
- Batch Prediction
- Scan Protein Sequence
- MHC Class II Prediction
- Common HLA Alleles
- Related Skills
Install MHCflurry pip install mhcflurry Download prediction models mhcflurry-downloads fetch Download models for specific alleles mhcflurry-downloads fetch models_class1_pan
What does the bio-immunoinformatics-mhc-binding-prediction skill do?
Predict peptide-MHC class I and II binding affinity using MHCflurry and NetMHCpan neural network models. Identify potential T-cell epitopes from protein sequences. Use when predicting MHC binding for vaccine design or neoantigen identification.
How do I install it?
Run `npx skills add FreedomIntelligence/OpenClaw-Medical-Skills --skill bio-immunoinformatics-mhc-binding-prediction --agent claude-code` — it drops the skill into your project so the agent can pick it up. Swap the --agent value for codex, cursor or copilot if you use one of those.
Where does this skill come from?
From FreedomIntelligence/OpenClaw-Medical-Skills, a repository with 2,909 stars. We read it straight from the repository tree rather than a submitted listing, so what you see here is what is actually published.
Is a popular skill a good skill?
Not necessarily. Stars measure attention, not adoption — a repository can trend for a week and be abandoned. That is why we show the weekly change from our own snapshots next to the total, instead of a single flattering number.