bio-genome-engineering-base-editing-design
Design guides for cytosine and adenine base editing using editing window optimization and BE-Hive outcome prediction. Select optimal positions for C-to-T or A-to-G conversions without double-strand breaks. Use when designing base editor experiments for precise nucleotide changes.
npx skills add FreedomIntelligence/OpenClaw-Medical-Skills --skill bio-genome-engineering-base-editing-design --agent claude-code
Same command for any agent — swap --agent for codex, cursor, copilot.
Weekly change comes from our own snapshots, not the repository page — it measures attention, not adoption.
## Version Compatibility Reference examples tested with: BioPython 1.83+ Before using code patterns, verify installed versions match. If versions differ: - Python: `pip show <package>` then `help(module.function)` to check signatures If code throws ImportError, AttributeError, or TypeError, introspect the installed package and adapt the example to match the actual API rather than retrying. # Base Editing Design **"Design a base editor guide for my C-to-T conversion"** → Identify guide sequences that position the target nucleotide within the editing window of cytosine (CBE) or adenine (ABE) base editors, predicting editing outcomes and bystander effects. - Python: editing window analysis with `Bio.Seq`, BE-Hive outcome prediction ## Base Editor Types ``` Cytosine Base Editors (CBE): - Convert C to T (or G to A on opposite strand) - Examples: BE3, BE4, BE4max, AncBE4max - Editing window: Positions 4-8 (PAM-distal numbering) Adenine Base Editors (ABE): - Convert A to G (or T to C on opposite strand) - Examples: ABE7.10, ABE8e, ABE8.20 - Editing window: Positions 4-7 (narrower than CBE) Position numbering: Position 1 = PAM-proximal (next to NGG) Position 20 = PAM-distal (5' end of spac
- Version Compatibility
- Base Editor Types
- Find Editable Positions
- Editing Efficiency by Position
- Bystander Edit Prediction
- Dual Base Editor Design
- Sequence Context Effects
- Related Skills
What does the bio-genome-engineering-base-editing-design skill do?
Design guides for cytosine and adenine base editing using editing window optimization and BE-Hive outcome prediction. Select optimal positions for C-to-T or A-to-G conversions without double-strand breaks. Use when designing base editor experiments for precise nucleotide changes.
How do I install it?
Run `npx skills add FreedomIntelligence/OpenClaw-Medical-Skills --skill bio-genome-engineering-base-editing-design --agent claude-code` — it drops the skill into your project so the agent can pick it up. Swap the --agent value for codex, cursor or copilot if you use one of those.
Where does this skill come from?
From FreedomIntelligence/OpenClaw-Medical-Skills, a repository with 2,909 stars. We read it straight from the repository tree rather than a submitted listing, so what you see here is what is actually published.
Is a popular skill a good skill?
Not necessarily. Stars measure attention, not adoption — a repository can trend for a week and be abandoned. That is why we show the weekly change from our own snapshots next to the total, instead of a single flattering number.