bio-fragment-analysis
Analyzes cfDNA fragment size distributions and fragmentomics features using FinaleToolkit or Griffin. Extracts nucleosome positioning patterns, fragment ratios, and DELFI-style fragmentation profiles for cancer detection. Use when leveraging fragment patterns for tumor detection or tissue-of-origin analysis.
npx skills add FreedomIntelligence/OpenClaw-Medical-Skills --skill bio-fragment-analysis --agent claude-code
Same command for any agent — swap --agent for codex, cursor, copilot.
Weekly change comes from our own snapshots, not the repository page — it measures attention, not adoption.
## Version Compatibility Reference examples tested with: numpy 1.26+, pandas 2.2+, pysam 0.22+ Before using code patterns, verify installed versions match. If versions differ: - Python: `pip show <package>` then `help(module.function)` to check signatures If code throws ImportError, AttributeError, or TypeError, introspect the installed package and adapt the example to match the actual API rather than retrying. # Fragment Analysis **"Analyze cfDNA fragment patterns for cancer detection"** → Extract fragmentomics features (size distributions, nucleosome positioning, DELFI profiles) from cfDNA for tumor detection and tissue-of-origin analysis. - Python: `FinaleToolkit` or `Griffin` for fragment feature extraction - Python: `pysam` for custom fragmentomics analysis Analyze cfDNA fragmentomics for cancer detection and characterization. ## Tool Selection | Tool | Description | Use Case | |------|-------------|----------| | FinaleToolkit | DELFI-style patterns, MIT license | General fragmentomics | | Griffin | Nucleosome profiling | Tissue deconvolution | Note: DELFI is a commercial company, NOT software. Use FinaleToolkit (MIT license) which replicates DELFI patterns and is 50x faster.
- Version Compatibility
- Tool Selection
- Fragment Size Metrics
- FinaleToolkit Analysis
- Griffin Nucleosome Profiling
- Genome-Wide Fragmentation Profile
- Interpretation
- Related Skills
What does the bio-fragment-analysis skill do?
Analyzes cfDNA fragment size distributions and fragmentomics features using FinaleToolkit or Griffin. Extracts nucleosome positioning patterns, fragment ratios, and DELFI-style fragmentation profiles for cancer detection. Use when leveraging fragment patterns for tumor detection or tissue-of-origin analysis.
How do I install it?
Run `npx skills add FreedomIntelligence/OpenClaw-Medical-Skills --skill bio-fragment-analysis --agent claude-code` — it drops the skill into your project so the agent can pick it up. Swap the --agent value for codex, cursor or copilot if you use one of those.
Where does this skill come from?
From FreedomIntelligence/OpenClaw-Medical-Skills, a repository with 2,909 stars. We read it straight from the repository tree rather than a submitted listing, so what you see here is what is actually published.
Is a popular skill a good skill?
Not necessarily. Stars measure attention, not adoption — a repository can trend for a week and be abandoned. That is why we show the weekly change from our own snapshots next to the total, instead of a single flattering number.