bio-differential-splicing
Detects differential alternative splicing between conditions using rMATS-turbo (BAM-based) or SUPPA2 diffSplice (TPM-based). Reports events with FDR-corrected significance and delta PSI effect sizes. Use when comparing splicing patterns between treatment groups, tissues, or disease states.
npx skills add FreedomIntelligence/OpenClaw-Medical-Skills --skill bio-differential-splicing --agent claude-code
Same command for any agent — swap --agent for codex, cursor, copilot.
Weekly change comes from our own snapshots, not the repository page — it measures attention, not adoption.
## Version Compatibility Reference examples tested with: STAR 2.7.11+, pandas 2.2+ Before using code patterns, verify installed versions match. If versions differ: - Python: `pip show <package>` then `help(module.function)` to check signatures - R: `packageVersion('<pkg>')` then `?function_name` to verify parameters - CLI: `<tool> --version` then `<tool> --help` to confirm flags If code throws ImportError, AttributeError, or TypeError, introspect the installed package and adapt the example to match the actual API rather than retrying. # Differential Splicing Detect differential alternative splicing events between experimental conditions. ## Tool Comparison | Tool | Input | Approach | Strengths | |------|-------|----------|-----------| | rMATS-turbo | BAM | Junction counting | Novel junctions, statistical model | | SUPPA2 | TPM | Transcript ratios | Speed, isoform-aware | | leafcutter | BAM | Intron clustering | Novel events, no annotation bias | ## rMATS-turbo Analysis **Goal:** Detect statistically significant differential splicing events between two conditions from BAM files. **Approach:** Run rMATS-turbo on condition-grouped BAMs, then filter results by FDR and delta PSI thresho
- Version Compatibility
- Tool Comparison
- rMATS-turbo Analysis
- SUPPA2 Differential Analysis
- leafcutter Analysis
- Significance Thresholds
- Result Prioritization
- Related Skills
Create sample lists (one BAM path per line) rmats.py \
What does the bio-differential-splicing skill do?
Detects differential alternative splicing between conditions using rMATS-turbo (BAM-based) or SUPPA2 diffSplice (TPM-based). Reports events with FDR-corrected significance and delta PSI effect sizes. Use when comparing splicing patterns between treatment groups, tissues, or disease states.
How do I install it?
Run `npx skills add FreedomIntelligence/OpenClaw-Medical-Skills --skill bio-differential-splicing --agent claude-code` — it drops the skill into your project so the agent can pick it up. Swap the --agent value for codex, cursor or copilot if you use one of those.
Where does this skill come from?
From FreedomIntelligence/OpenClaw-Medical-Skills, a repository with 2,909 stars. We read it straight from the repository tree rather than a submitted listing, so what you see here is what is actually published.
Is a popular skill a good skill?
Not necessarily. Stars measure attention, not adoption — a repository can trend for a week and be abandoned. That is why we show the weekly change from our own snapshots next to the total, instead of a single flattering number.