bio-clinical-databases-gnomad-frequencies
Query gnomAD for population allele frequencies to assess variant rarity. Use when filtering variants by population frequency for rare disease analysis or determining if a variant is common in the general population.
npx skills add FreedomIntelligence/OpenClaw-Medical-Skills --skill bio-clinical-databases-gnomad-frequencies --agent claude-code
Same command for any agent — swap --agent for codex, cursor, copilot.
Weekly change comes from our own snapshots, not the repository page — it measures attention, not adoption.
## Version Compatibility Reference examples tested with: requests 2.31+, pandas 2.2+ Before using code patterns, verify installed versions match. If versions differ: - Python: `pip show <package>` then `help(module.function)` to check signatures If code throws ImportError, AttributeError, or TypeError, introspect the installed package and adapt the example to match the actual API rather than retrying. # gnomAD Frequency Queries ## gnomAD REST API **Goal:** Retrieve exome and genome allele frequencies from gnomAD for individual variants. **Approach:** Send a GraphQL query to the gnomAD API with variant ID and dataset version, then parse exome/genome frequency fields. **"Check how common this variant is in the population"** → Query gnomAD for allele frequency, allele count, and homozygote count. - Python: GraphQL via `requests.post()` (requests) - Python: `myvariant.MyVariantInfo().getvariant()` (myvariant) ### Query Single Variant ```python import requests def query_gnomad(chrom, pos, ref, alt, dataset='gnomad_r4'): '''Query gnomAD API for variant frequency dataset options: gnomad_r4, gnomad_r3, gnomad_r2_1 ''' url = 'https://gnomad.broadinstitute.org/api' query = ''' query ($varian
- Version Compatibility
- gnomAD REST API
- Query Single Variant
- Parse gnomAD Response
- Query via myvariant.info
- Population-Specific Frequencies
- Filtering Thresholds
- Filter Variants by Frequency
- Batch Query with Local gnomAD
- Related Skills
What does the bio-clinical-databases-gnomad-frequencies skill do?
Query gnomAD for population allele frequencies to assess variant rarity. Use when filtering variants by population frequency for rare disease analysis or determining if a variant is common in the general population.
How do I install it?
Run `npx skills add FreedomIntelligence/OpenClaw-Medical-Skills --skill bio-clinical-databases-gnomad-frequencies --agent claude-code` — it drops the skill into your project so the agent can pick it up. Swap the --agent value for codex, cursor or copilot if you use one of those.
Where does this skill come from?
From FreedomIntelligence/OpenClaw-Medical-Skills, a repository with 2,909 stars. We read it straight from the repository tree rather than a submitted listing, so what you see here is what is actually published.
Is a popular skill a good skill?
Not necessarily. Stars measure attention, not adoption — a repository can trend for a week and be abandoned. That is why we show the weekly change from our own snapshots next to the total, instead of a single flattering number.